Citation

Adkins B, Luginbuhl GH, Gardner DE. J. Toxicol. Environ. Health 1980; 6(2): 445-454.

Copyright

(Copyright © 1980, Informa - Taylor and Francis Group)

DOI

10.1080/15287398009529863

PMID

7392103

Abstract

Inhalation of manganese oxide (Mn dose, 879.0 micrograms/m3) for 2 h reduced the total number of alveolar macrophages obtained by endotracheal lavage in pulmonary cell populations, slightly reduced cellular viability, and reduced both phagocytic capability and total protein in sonicated pulmonary cells. Increases in intracellular adenosine triphosphate and acid phosphatase specific activity were also exhibited by the pulmonary cells, but sonicated cells obtained from the exposed mice showed no change in lactic acid dehydrogenase specific activity. A slight increase in extracellular protein in the fluid phase of the lavage suspension was observed after manganese oxide exposure.

Language: en