Citation

Smith C, Krygsman A. J. Ethnopharmacol. 2014; 155(2): 987-991.

Affiliation

Department Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.

Copyright

(Copyright © 2014, Elsevier Publishing)

DOI

10.1016/j.jep.2014.06.033

PMID

24955559

Abstract

Ethnopharmacological relevance: Hoodia gordonii (family Apocynaceae) has become known globally for its claimed effect of appetite suppression. Despite a relatively large body of evidence of the plant's chemical make-up, peer-reviewed studies to provide scientific information on physiological effects of Hoodia gordonii are relatively sparse. The role of the pregnane glycoside P57 - commonly accepted to be responsible for appetite suppression - has been questioned recently. Furthermore, a variety of physiological side-effects associated with consumption of the plant in extracted form questions its suitability for consumption. Although adverse effects have been described before, the relative abundance of non-peer-reviewed data originating from patent documents and lay publication for advertising, which specifically only focus on beneficial outcomes, skews the view of the risk-benefit-balance. Here we provide a review of peer-reviewed studies on the plant's physiological effects. Novel data from an in vivo rodent study further elucidate the benefit-to-risk ratio associated with consumption.

CONCLUSIONS: We conclude that although Hoodia gordonii seems to have a desired effect on appetite and weight loss, this effect may at least in part be a secondary symptom of the serious adverse effects that are associated with consumption of the high doses required to achieve therapeutic clinical effect.

Language: en