Citation

Lindsay DL, Pajtek S, Tarter RE, Long EC, Clark DB. J. Child Adolesc. Subst. Abuse 2014; 23(3): 200-204.

Copyright

(Copyright © 2014, Informa - Taylor and Francis Group)

DOI

10.1080/1067828X.2014.889515

PMID

unavailable

Abstract

Studies are needed that examine neurobiological characteristics in high-risk individuals prior to substance use disorder (SUD) development. In this pilot study, 4 adolescent subjects at high risk for SUD (having at least 1 parent with an SUD) were compared with 4 adolescent reference subjects on a cortico-limbic reactivity paradigm, where they were presented with affect-laden faces or geometric shapes. Functional magnetic resonance imaging was used to measure cortical activation in response to these stimuli. High-risk subjects, compared to low-risk, exhibited greater left amygdala activation (t = 2.76, df = 6, p = 0.03), suggesting they may exhibit hyperresponsivity of the amygdala in response to emotional stimuli.

Language: en