Citation

Sanders DC, Endecott BR. J. Fire Sci. 1991; 9(4): 296-310.

Copyright

(Copyright © 1991, SAGE Publishing)

DOI

unavailable

PMID

unavailable

Abstract

Laboratory rats were exposed to experimental concentrations of carbon monoxide in air at ambient temperature, to elevated temperature atmospheres from 40-degrees-C to 60-degrees-C, and to selected CO concentrations in 40-60-degrees-C whole-body environments. Incapacitating potency was evaluated by measuring time-to-incapacitation as a function of CO concentration and/or temperature. Incapacitation occurred earlier when CO inhalation was combined with elevated temperature than when the same parameters were applied individually; a fractionally additive effect was noted. An empirical equation was derived for predicting time-to-incapacitation from CO concentration and temperature data.