Citation

Geraldo AF, Silva C, Neutel D, Neto LL, Albuquerque L. J. Radiol. Case Rep. 2014; 8(5): 1-8.

Affiliation

Department of Neurosciences (Neurology), Hospital de Santa Maria (CHLN, EPE), Lisbon, Portugal ; Lisbon School of Medicine, Lisbon, Portugal.

Copyright

(Copyright © 2014, Journal of radiology case reports)

DOI

10.3941/jrcr.v8i5.1721

PMID

25426224

PMCID

PMC4242060

Abstract

Delayed leukoencephalopathy is an uncommon complication of hypoxic-ischemic events of different etiologies, including carbon monoxide intoxication. We present a case of a 40-year-old male patient who was admitted with rapidly progressive neurocognitive and behavioral deficits. There was a history of accidental carbon monoxide intoxication one month before, presenting with loss of consciousness and short hospitalization, followed by a complete clinical recovery. The imaging studies in the delayed phase depicted confluent, symmetric supra-tentorial white matter lesions in keeping with diffuse demyelinization. Restricted diffusion and metabolite abnormalities in magnetic resonance proton spectroscopy were also seen. The diagnosis of CO-mediated delayed post-hypoxic leukoencephalopathy was assumed after exclusion of other mimickers. Hyperbaric oxygen therapy was tentatively performed and the patient had a favorable clinical and radiological evolution.

Language: en