Citation

Yamamoto T, Yoshizawa K, Kubo S, Emoto Y, Hara K, Waters B, Umehara T, Murase T, Ikematsu K. J. Toxicol. Pathol. 2015; 28(1): 33-36.

Affiliation

Division of Forensic Pathology and Science, Unit of Social Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, Nagasaki 852-8523, Japan.

Copyright

(Copyright © 2015, Japanese Society of Toxicologic Pathology)

DOI

10.1293/tox.2014-0044

PMID

26023259

PMCID

PMC4337497

Abstract

Caffeine (1,3,7-trimethylxanthine) is a popular mild central nervous system stimulant found in the leaves, seeds and fruits of various plants and in foodstuffs such as coffee, tea, and chocolate, among others. Caffeine is widely used and is not associated with severe side effects when consumed at relatively low doses. Although rarely observed, overdoses can occur. However, only a few fatal caffeine intoxication cases have been reported in the literature. Herein, we report the pathological examination results and information on caffeine concentrations in the blood, urine and main organs in a fatal caffeine intoxication case. Even though high caffeine concentrations were found in the systemic organs, no caffeine-related pathological changes were detected.

Language: en