Citation

Ladjel-Mendil A, Martin-Eauclaire MF, Laraba-Djebari F. J. Biochem. Mol. Toxicol. 2016; 30(12): 580-587.

Affiliation

USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria. flaraba@hotmail.com, flaraba@usthb.dz.

Copyright

(Copyright © 2016, John Wiley and Sons)

DOI

10.1002/jbt.21824

PMID

27271987

Abstract

Kaliotoxin (KTX), a specific blocker of potassium channels, exerts various toxic effects due to its action on the central nervous system. Its use in experimental model could help the understanding of the cellular and molecular mechanisms involved in the neuropathological processes related to potassium channel dysfunctions. In this study, the ability of KTX to stimulate neuro-immuno-endocrine axis was investigated. As results, the intracerebroventricular injection of KTX leads to severe structural-functional alterations of both hypothalamus and thyroid. These alterations were characterized by a massive release of hormones' markers of thyroid function associated with damaged tissue which was infiltrated by inflammatory cell and an imbalanced redox status. Taken together, these data highlight that KTX is able to modulate the neuro-endocrine response after binding to its targets leading to the hypothalamus and the thyroid stimulation, probably by inflammatory response activation and the installation of oxidative stress in these organs.

© 2016 Wiley Periodicals, Inc.

Language: en