Citation

Ji H, Zhang G, Yue F, Zhou X. J. Clin. Pharm. Ther. 2017; 42(2): 237-238.

Affiliation

Department of Nephrology, Yancheng Third People's Hospital, Jiangsu, China.

Copyright

(Copyright © 2017, John Wiley and Sons)

DOI

10.1111/jcpt.12500

PMID

28144968

Abstract

WHAT IS KNOWN AND OBJECTIVE: Drug-induced nephrotoxicity is potentially lethal. When sodium aescinate is given to surgical inpatients to treat postoperative inflammation and oedema, adverse drug reactions and drug-drug interactions must be closely monitored. CASE DESCRIPTION: We report a case of a 58-year-old man with phalangeal fractures who suffered from acute kidney injury that was most likely induced by the drug interaction between sodium aescinate and ginkgo biloba extract due to the protein-binding and metabolic characteristics of these drugs. WHAT IS NEW AND CONCLUSION: Close monitoring and the prompt discontinuation of drugs that have high protein-binding capacity and hepatic metabolism are necessary to avoid drug-drug interactions in patients who are treated with sodium aescinate.

© 2017 John Wiley & Sons Ltd.

Language: en

Keywords

adverse effect; drug-drug interactions; metabolism