Citation

Wiergowski M, Aszyk J, Kaliszan M, Wilczewska K, Anand JS, Kot-Wasik A, Jankowski Z. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2017; 1041-1042: 1-10.

Copyright

(Copyright © 2017, Elsevier Publishing)

DOI

10.1016/j.jchromb.2016.12.018

PMID

unavailable

Abstract

This paper describes cases of poisoning caused by new psychoactive substances such as: 25B-NBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4‐CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC-MS/MS technique. To the best of our knowledge, this is the first report, that involves a fully validated method for quantification of new-designer drug - 4-CMC in postmortem blood samples. The biological material was also analyzed with the use of routine analytical methods: immunochemical techniques, gas chromatography with flame ionization detection and gas chromatography with electron impact mass spectrometry. The results of real samples analyses correspond to possible toxicological effects: death resulting from 25B-NBOMe - mediated hallucinations (661 ng/mL of 25B‐NBOMe and 0.887 ng/mL of 4-CMC), fatal overdose of 25B-NBOMe and 4-CMC (66.5 ng/mL of 25B‐NBOMe and 2.14 ng/mL of 4-CMC) and non-fatal intoxication of these drugs (38.4 ng/mL of 25B NBOMe and 0.181 ng/mL of 4-CMC). Additionally, O-demethylathed O, O-bis-demethylathed and glucuronidated metabolites of 25B-NBOMe in biological specimens were detected.

Language: en