Citation

Van Horn JD, Irimia A, Torgerson CM, Bhattrai A, Jacokes Z, Vespa PM. J. Neurosci. Res. 2018; 96(4): 652-660.

Affiliation

Department of Neurosurgery, University of California Los Angeles, Los Angeles, California.

Copyright

(Copyright © 2018, John Wiley and Sons)

DOI

10.1002/jnr.24084

PMID

28543689

Abstract

In this report, we present a case study involving an older, female patient with a history of pediatric traumatic brain injury (TBI). Magnetic resonance imaging and diffusion tensor imaging volumes were acquired from the volunteer in question, her brain volumetrics and morphometrics were extracted, and these were then systematically compared against corresponding metrics obtained from a large sample of older healthy control (HC) subjects as well as from subjects in various stages of mild cognitive impairment (MCI) and Alzheimer disease (AD). Our analyses find the patient's brain morphometry and connectivity most similar to those of patients classified as having early-onset MCI, in contrast to HC, late MCI, and AD samples. Our examination will be of particular interest to those interested in assessing the clinical course in older patients having suffered TBI earlier in life, in contradistinction to those who experience incidents of head injury during aging.

© 2017 Wiley Periodicals, Inc.

Language: en

Keywords

aging; mild cognitive impairment; traumatic brain injury