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Citation |
Dewan S, Schimmel S, Borlongan CV. Expert Opin. Biol. Ther. 2018; 18(5): 515-524. |
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Affiliation |
a Center of Excellence for Aging and Brain Repair, Department of Neurosugery and Brain Repair , University of South Florida Morsani College of Medicine , Tampa , FL , USA. |
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Copyright |
(Copyright © 2018, Informa - Taylor and Francis Group) |
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DOI |
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PMID |
29421958 |
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Abstract |
INTRODUCTION: Neonatal traumatic brain injury (TBI) is a significant cause of developmental disorders. Autologous stem cell therapy may enhance neonatal brain plasticity towards repair of the injured neonatal brain. Areas Covered: The endogenous neonatal anti-inflammatory response can be enhanced by biological treatments. Stem cell therapy stands as a robust approach for sequestering the inflammation-induced cell death in the injured brain. Here, we discuss the use of umbilical cord blood cells and bone marrow stromal cells for acute and chronic treatment of experimental neonatal TBI. Autologous stem cell transplantation may retard and possibly even halt this neuroinflammation-plagued secondary cell death. Clinical translation of this stem cell therapy will require identifying the therapeutic window post-injury and harvesting ample supply of transplantable autologous stem cells. Stem cell banking with access to cryopreserved cells may allow readily available transplantable cells in addressing the unpredictable nature of neonatal TBI. Harnessing the anti-inflammatory properties of stem cells is key in combating the progressive neurodegeneration after the initial injury. Expert Opinion: Combination treatments, such as with hypothermia, may enhance the therapeutic effects of stem cells. Stem cell therapy has potential as stand-alone or adjunctive therapy for treating neuroinflammation associated with acute and progressive stages of neonatal TBI. Language: en |
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Keywords |
Autologous; Bone marrow stromal cells; Hypoxic ischemic encephalopathy; Neonatal; Neuroinflammation; Neuroplasticity; Stem cells; Traumatic brain injury; Umbilical cord blood cells |