Citation

Richardson MB, Brown DB, Vasquez C, Ziller JW, Johnston KM, Weiss GA. J. Org. Chem. 2018; 83(8): 4525-4536.

Copyright

(Copyright © 2018, American Chemical Society)

DOI

10.1021/acs.joc.8b00270

PMID

29577718

Abstract

A reliable, scalable, cost-effective, and chromatography-free synthesis of 4-azido-L-phenylalanine beginning from L-phenylalanine is described. Investigations into the safety of the synthesis reveal that the Ullman-like Cu(I)-catalyzed azidation step does not represent a significant risk. The isolated 4-azido-L-phenylalanine product, however, exhibits previously undocumented explosive characteristics.

Language: en