Citation

Elgendy R, Deschênes SS, Burns RJ, Levy M, Schmitz N. J. Diabetes 2019; 11(1): 14-22.

Affiliation

Department of Epidemiology and Biostatistics, Faculty of Medicine, McGill University, Purvis Hall, 1020 Pine Avenue West, Montreal, QC, Canada, H3A 1A2.

Copyright

(Copyright © 2019, John Wiley and Sons)

DOI

10.1111/1753-0407.12822

PMID

29989328

Abstract

BACKGROUND: Heavy alcohol consumption in individuals with type 2 diabetes (T2D) is related to increased risk of diabetes-related micro- and macrovascular complications. Depressive symptoms may be relevant to consider in this relation, as high depressive symptoms are associated with increased risk of complications. We aimed to investigate whether the interaction between depressive symptoms and alcohol frequency will be positively related to development of neuropathy, retinopathy, nephropathy, and coronary artery disease (CAD), such that those with high depressive symptoms and high alcohol frequency will be at increased risk for complications.

METHODS: Data were from five waves of the Evaluation of Diabetes Treatment study, an annual survey including 1413 adults with T2D in Quebec, Canada. Data on alcohol frequency (number of drinking occasions), depressive symptoms, and complications were collected annually. Multiple logistic regression analyses with generalized estimating equations were used to investigate the development of each complication.

RESULTS: After adjusting for sociodemographic, lifestyle, and diabetes-related covariates, the interaction between alcohol frequency and depressive symptoms was positively related to incidence of neuropathy and CAD, such that those with high depressive symptoms who drank the most frequently had the highest risk of neuropathy (OR=1.02, p=.04, CI [1.00, 1.04]) and CAD (OR=1.02, p=.04, CI [1.00, 1.04]). This interaction was not significantly related to retinopathy or nephropathy.

CONCLUSION: Individuals with high depressive symptoms and high frequency of alcohol consumption may have a particularly high risk of neuropathy and CAD. Future prevention efforts should examine both alcohol frequency and depressive symptoms when evaluating risk of complications. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

Language: en

Keywords

Alcohol; depressive symptoms; diabetes-related complications; type 2 diabetes