Citation

Relja B, Horstmann JP. Exp. Suppl. (2012) 2018; 108: 85-110.

Affiliation

Department of Psychiatry and Psychotherapy, University Medicine Mainz, Mainz, Germany.

Copyright

(Copyright © 2018, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/978-3-319-89390-7_5

PMID

30536169

Abstract

Traumatic injury as one of the world's most relevant but neglected health concerns results in modulated inflammasome activity, which is closely linked to the development of post-injury complications. Cytokine-producing capacity of cells is important for the appropriate immune response to trauma and requires not only synthesis and transcription of inflammasome components but also their activation. Unfortunately, the precise role of inflammasome in trauma is still largely unknown. However, in the following chapter, we provide an overview on the best described inflammasomes in the various settings of trauma, introducing the recent findings on the up-to-date best described NLRP inflammasomes and underlying cytokines in the inflammatory response to trauma.

Language: en

Keywords

CARS; Immunosuppression; Inflammasome; Outcome; PTI; SIRS; Stress; Trauma