Citation

Walsh TJ, Hospenthal DR, Petraitis V, Kontoyiannis DP. J. Fungi (Basel) 2019; 5(3): e5030057.

Affiliation

Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Copyright

(Copyright © 2019, MDPI: Multidisciplinary Digital Publications Institute)

DOI

10.3390/jof5030057

PMID

31277364

Abstract

Necrotizing mucormycosis is a devastating complication of wounds incurred in the setting of military (combat) injuries, natural disasters, burns, or other civilian trauma. Apophysomyces species, Saksenaea species and Lichtheimia (formerly Absidia) species, although uncommon as causes of sinopulmonary mucormycosis, are relatively frequent agents of trauma-related mucormycosis. The pathogenesis of these infections likely involves a complex interaction among organism, impaired innate host defenses, and biofilms related to traumatically implanted foreign materials. Effective management depends upon timely diagnosis, thorough surgical debridement, and early initiation of antifungal therapy.

Language: en

Keywords

antifungal therapy; mucormycosis