Citation

Ghasemian R, Bandegani A, Kermani F, Faeli L, Roohi B, Yosefi Abdolmaleki E, Hedayati MT, Roilides E, Shokohi T. Curr. Med. Mycol. 2021; 7(4): 38-42.

Copyright

(Copyright © 2021, Mazandaran University of Medical Sciences)

DOI

10.18502/cmm.7.4.8410

PMID

unavailable

Abstract

Background and Purpose: Scedosporium spp. is a saprophytic fungus that may cause invasive pulmonary infection due to the aspiration of contaminated water in both immunosuppressed and immunocompetent hosts.Case report: Herein, we report a fatal case of pulmonary infection caused by Scedosporium species associated with a car crash and near-drowning in a sewage canal.Scedosporium aurantiacum isolated from bronchoalveolar lavage was identified by PCR-sequencing of β-tubulin genes. The minimum inhibitory concentration values for amphotericin B, itraconazole, posaconazole, isavuconazole were >16 µg/ml, and >8 µg/ml for anidulafungin, micafungin, and caspofungin. Voriconazole was found to be the most active agent with a MIC of 1 µg/ml.

CONCLUSION: This report, as the first case of pulmonary scedosporiosis after near-drowningin Iran, highlights the importance of high suspicion in near-drowning victims, promptidentification of Scedosporium spp., and early initiation of appropriate antifungal therapy.

Language: en