Citation

Cheng X, Sheng ZF, Wang X. Front. Endocrinol. (Lausanne) 2022; 13: e1107678.

Copyright

(Copyright © 2022, Frontiers Research Foundation)

DOI

10.3389/fendo.2022.1107678

PMID

36601004

PMCID

PMC9807225

Abstract

Osteoporosis is a metabolic skeletal disorder that is characterized by low bone mineral density (BMD), a deterioration of the microstructure of bone tissue, and a decrease in bone strength, leading to an increase in bone fragility and the risk of fractures (1). Symptomatic vertebral and hip fragility fractures are severe osteoporotic fractures that limit the quality of life and increase morbidity and mortality [(2), Shen et al, (3)]. Currently, a total of 10.9 million men and 49.3 million women in China are estimated to have osteoporosis (4). Meanwhile, it has been estimated that world-wide, there were 158 million individuals aged 50 years or older at high fracture risk in 2010, and that number is expected to double by 2040, predominantly in Asia (5). Therefore, early screening for osteoporosis has a significant role in controlling the disease and lowering the prevalence of osteoporotic fractures.

Although great advances have been achieved in surgical strategies for the treatment of osteoporotic fractures, information on the early assessment of osteoporotic fractures remains limited. Therefore, we organized this special issue that aims to provide insight into the etiology and pathogenesis of osteoporotic fractures, such as the connections between bone mineral density, bone mineral content, and muscle, focusing on clinical research related to the diagnosis, prevention, treatment, and monitoring of osteoporotic fracture. We received more contributions on this topic than originally anticipated, so we have expanded the special issue into a two-volume collection...

Language: en

Keywords

Humans; risk factors; assessment; prediction; *Osteoporosis/complications/diagnosis; *Osteoporotic Fractures/epidemiology; Bone Density; fracture; osteoporosis