Citation

Toups EG, Ugiliweneza B, Howley SP, Neal CJ, Harrop JS, Guest J, Grossman R, Fehlings MG. J. Neurotrauma 2023; ePub(ePub): ePub.

Copyright

(Copyright © 2023, Mary Ann Liebert Publishers)

DOI

10.1089/neu.2022.0403

PMID

37125443

Abstract

The North American Clinical Trials Network (NACTN) for Spinal Cord Injury (SCI) is a consortium of neurosurgery departments at university affiliated hospitals with medical, nursing and rehabilitation personnel who are skilled in the assessment, evaluation and management of SCI. NACTN was established with the goal of consistently advancing the quality of life of people with SCI through clinical trials of new therapies that provide robust evidence of safety and effectiveness. A prospective multicenter Registry was created to collect the natural course of the acute traumatic SCI patient from time of injury to 12 months follow-up. NACTN's network of hospitals enrolls a significant number of patients, defines and adheres to standard protocols and provides the infrastructure and highly skilled personnel to conduct trials of therapy for SCI. Registry data have been used by academic institutions and by the biotechnology and pharmaceutical sectors to create comparison datasets for Phase I clinical trials of new therapies.

Language: en

Keywords

CLINICAL MANAGEMENT OF CNS INJURY; spinal cord injury; TRAUMATIC SPINAL CORD INJURY