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Citation |
Tian L, Lai F, Zhang Y, Weng X, Yao S, Ren W. China Saf. Sci. J. 2022; 32(10): 207-213. |
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Copyright |
(Copyright © 2022, China Occupational Safety and Health Association, Publisher Gai Xue bao) |
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DOI |
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PMID |
unavailable |
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Abstract |
In order to explore characters of kidney injuries caused by gas explosion and treatment effect of MET as well as its possible action mechanism, rat samples were divided into normal control group (NC group), kidney injury caused by gas explosion group (SW group) and kidney injury caused by gas explosion treated with MET group randomly. Then, kidney injury model of rats was built by utilizing actual roadway, renal functions were tested, histological changes of kidney and express changes of apoptosis associated molecular were observed, and those of AMPK and PGC-1琢 were detected. The results show that kidney injuries are normally expressed as significant congestion and edema in renal corpuscle and kidney tubules along with kidney disfunction. MET can improve renal function and decrease damages probably through activating AMPK and PGC-1琢, thus inhibiting apoptosis of renal tubular epithelial cells. © 2022 China Safety Science Journal. All rights reserved. Language: zh |