Citation

Hagiwara S, Ogino T, Takahashi Y, Isaka A, Nameki T, Kagoshima K, Yamada T, Ishihara K, Hiraishi H, Kurabayashi K, Handa H, Iino Y. Kitakanto Med. J. 2007; 57(4): 317-320.

Copyright

(Copyright © 2007, Kitakanto Medical Society, Publisher Kita Kantō Igakkai)

DOI

10.2974/kmj.57.317

PMID

unavailable

Abstract

Tegafur/uracil (UFT) is an oral anticancer drug composed of tegafur which is a derivative of fluorouracil (5-FU) and uracil in a molar ratio of 1:4. UFT is effective as adjuvant chemotherapy for breast cancer2, colorectal cancer3, non-small cell lung carcinoma4, head and neck cancer5 and other tumors. We report a 41-year-old man who orally ingested a large dose of UFT (tegafur: 40000 mg/uracil 9960mg) in an effort to commit suicide, and suffered from sub-acute toxicosis (main symptoms were bone-marrow suppression, and hair loss) of UFT. His life was saved by empiric antibiotic chemical treatment (meropenem, isapamicin, and micafungin), and granulocyte colony-stimulating factor (G -CSF). In the case of toxicosis of UFT, strong antibacterial empiric chemotherapy and G-CSF are necessary for rescue. If G-CSF is not work, biopsy of bone marrow woud be necessary, and the case of no stem cells, bone marrow transfusion should be thought.

Language: en

Keywords

Suicide attempt; Pancytopenia; Tegafur/uracil (UFT); Toxicosis