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Citation |
Saito T, Nakamura M, Shimizu T, Oda K, Ishiwata K, Ishii K, Isse K. J. Neuroimaging. 2010; 20(2): 189-191. |
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Copyright |
(Copyright © 2010, Wiley) |
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DOI |
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PMID |
unavailable |
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Abstract |
Idiopathic basal ganglia calcification (IBGC) is a neuropathological condition known to manifest as motor disturbance, cognitive impairment, and psychiatric symptoms. The pathophysiology of the psychiatric symptoms of IBGC, however, remains controversial. A previous biochemical study suggested that dopaminergic impairment is involved in IBGC. We thus hypothesized that dopaminergic dysfunction might be related with the psychiatric manifestations of IBGC. We used positron emission tomography to measure glucose metabolism and dopaminergic function in the basal ganglia of an IBGC patient with psychiatric symptoms. The results showed that widespread hypometabolism was evident in the frontal, temporal, and parietal cortices while the decline in dopaminergic function was severe in the bilateral striatum. The functional decline of the dopamine system in the calcified area of the bilateral striatum and the disruption of cortico-subcortical circuits may contribute to clinical manifestations of IBGC in our patient. © 2008 by the American Society of Neuroimaging. Language: en |
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Keywords |
Humans; Adult; Female; adult; human; female; case report; suicidal ideation; psychosis; suicide attempt; mood disorder; Dopamine; neuroimaging; article; radiopharmaceutical agent; unclassified drug; lithium carbonate; dopamine; electroconvulsive therapy; trazodone; extrapyramidal symptom; risperidone; extrapyramidal syndrome; drug withdrawal; agitation; parkinsonism; carbon 11; positron emission tomography; metabolism; glucose metabolism; nigroneostriatal system; caudate nucleus; globus pallidus; frontal cortex; Catatonia; drug substitution; corpus striatum; Corpus Striatum; fluorodeoxyglucose f 18; PET; putamen; scintiscanning; DOPA; Basal Ganglia Diseases; parietal lobe; temporal cortex; analogs and derivatives; Dihydroxyphenylalanine; Radiopharmaceuticals; echolalia; 3beta (4 fluorophenyl) 2beta tropanecarboxylic acid methyl ester c 11; 6 fluorodopa f 18; brain calcification; CFT; dentate nucleus; diagnostic use; idiopathic basal ganglia calcification; Idiopathic basal ganglia calcification; pulvinar; RAC; raclopride c 11 |