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Citation |
Etiévant A, Lambs-Seas L, Abrial E, Bétry C, Haddjeri N, Lucas G. Neuropsychiatry (London) 2011; 1(2): 165-177. |
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Copyright |
(Copyright © 2011, Future Medicine) |
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DOI |
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PMID |
unavailable |
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Abstract |
The search for fast-acting antidepressants has been a major challenge in neuropsychopharmacology for many years. Although the involvement of serotonin (5-HT) in the mechanisms of action of classical antidepressants has been clearly established, the delayed onset of action of these drugs prompted several authors to propose alternative targets in order to achieve a more rapid relief of symptoms in depressed patients. However, recent studies indicate that it may be possible to elaborate fast-acting antidepressant strategies based on 5-HT, provided that such strategies would directly target 5-HT neuron electrical activity. Furthermore, glutamatergic pyramidal neurons projecting from the medial prefrontal cortex to the dorsal raphé appear to play a critical role. This article presents some of the data that support this hypothesis, including results from medial prefrontal cortex deep-brain stimulation studies, as well as those related to treatments with 5-HT4 agonists and 5-HT7 antagonists. © 2011 Future Medicine Ltd. Language: en |
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Keywords |
human; suicide; depression; prefrontal cortex; review; citalopram; serotonin antagonist; serotonin uptake inhibitor; unclassified drug; priority journal; electroconvulsive therapy; neurotransmission; nonhuman; psychopharmacotherapy; drug potentiation; drug efficacy; olanzapine; risperidone; high risk patient; drug effect; amisulpride; cisapride; tranquilizing activity; receptor upregulation; serotoninergic nerve cell; aripiprazole; brain depth stimulation; dorsal raphe nucleus; clinical effectiveness; nerve cell plasticity; receptor blocking; glutamic acid; pyramidal nerve cell; nerve conduction; glia cell; antidepressant activity; 1 (4 amino 5 chloro 2 methoxyphenyl) 3 (1 butyl 4 piperidinyl) 1 propanone; 3 [2 [2 (4 methyl 1 piperidinyl)ethyl] 1 pyrrolidinesulfonyl]phenol; medical prefrontal cortex; prucalopride; renzapride; serotonin 4 agonist; serotonin 4 receptor; serotonin 7 receptor; serotonin 7 receptor antagonist; sl 65 0155; target cell |