Citation

Gos T, Bogerts B, Steiner J. Nervenheilkd. 2011; 30(11): 909-913.

Copyright

(Copyright © 2011, Georg Thieme Verlag)

DOI

10.1055/s-0038-1628445

PMID

unavailable

Abstract

In our review we present postmortem results from the Magdeburg Brain Bank related to the evaluation of impaired activity of neuronal networks relevant for depression. Chronic changes in ribosomal DNA activity in neurons of prefrontal limbic regions, the amygdala, the striato-pallidal complex, and the serotonergic dorsal raphe nucleus have been revealed by quantitative evaluation of silver-stained nucleolar organising regions (AgNORs). The impact of processes leading to suicide has been accentuated in opposite to the weak influence of unipolar-bipolar dichotomy. Our results support the view that suicide and depression are phenomena of overlapping but distinct neurobiology. They suggest also that new specific therapeutic strategies are needed to prevent more effectively brain abnormalities related to suicide. © Schattauer 2011.

Language: de

Keywords

suicide; autopsy; Bipolar disorder; depression; prefrontal cortex; major depression; bipolar depression; Major depression; review; neurobiology; electroencephalogram; nerve cell; dorsal raphe nucleus; amygdaloid nucleus; AgNOR staining; silver staining; Post mortem; nerve cell network; ribosome DNA