Citation

Morrissette DA, Cutler AJ. CNS Spectr. 2012; 17(1): 31-41.

Copyright

(Copyright © 2012, MBL Communications)

DOI

10.1017/S1092852912000405

PMID

unavailable

Abstract

Medication nonadherence is a common problem in the treatment of schizophrenia. The consequences of nonadherence are numerous and can be quite serious, including increased risk of rehospitalization and suicide. There are numerous factors that affect a patient's decision and ability to take medication, including medication efficacy and tolerability, treatment regimen, cognitive deficits, and the patient's relationship with the treatment team. Fortunately, there are several strategies that may increase treatment adherence, including individualization of medication selection and dosing strategy to maximize efficacy and minimize adverse side effects, utilization of long-acting injectable depot formulations that eliminate the need for the patient to remember daily oral medication, and psychosocial approaches that emphasize the benefits of staying well. © Cambridge University Press 2012.

Language: en

Keywords

human; cognition; schizophrenia; Cognitive deficits; clozapine; article; neuroleptic agent; sexual dysfunction; clinical feature; sedation; life satisfaction; patient monitoring; priority journal; quetiapine; drug safety; follow up; patient compliance; drug efficacy; extrapyramidal symptom; olanzapine; risperidone; tardive dyskinesia; drug tolerability; weight gain; extrapyramidal syndrome; drug withdrawal; hyperprolactinemia; cardiovascular disease; side effect; atypical antipsychotic agent; ziprasidone; Side effects; drug formulation; perphenazine; aripiprazole; Atypical antipsychotics; working memory; outcome assessment; dopamine transporter; paliperidone; verbal memory; asenapine; Psychosocial; process optimization; iloperidone; lurasidone; Long-acting depot