Citation

Rocha S, Monteiro A, Linhares P, Chamadoira C, Basto MA, Reis C, Sousa C, Lima J, Rosas MJ, Massano J, Vaz R. Parkinsons Dis. 2014; 2014.

Copyright

(Copyright © 2014, SAGE Publishing)

DOI

10.1155/2014/717041

PMID

unavailable

Abstract

Background. Few data have been published regarding long-term mortality in patients with Parkinson's disease treated with DBS.

METHODS. This study analyzed long-term mortality rates, causes, and correlates in PD patients treated with DBS.

RESULTS. 184 consecutive patients were included; mean follow-up was 50 months. Fifteen deaths occurred (total 8.15%, annual mortality rate 1.94%). Mean age at disease onset and at surgery was 48±2.4 and 63±1.6 years, respectively. Mean disease duration until death was 21±7.8 years. Most deaths related to stroke, myocardial infarction, other vascular/heart disorders, or severe infection; one suicide was recorded. Deceased PD patients were mostly male and had lower motor benefit after DBS, but univariate analysis failed to show significant differences regarding gender and motor benefit. Survival was 99% and 94% at 3 and 5 years.

CONCLUSIONS. Long-term survival is to be expected in PD patients treated with DBS, possibly higher than previously expected. Death usually supervenes due to vascular events or infection. © 2014 Sofia Rocha et al.

Language: en

Keywords

adult; human; gender; suicide; female; male; dementia; traumatic brain injury; subdural hematoma; depression; cause of death; mortality; comorbidity; article; major clinical study; priority journal; middle aged; heart infarction; cardiomyopathy; cerebrovascular accident; sepsis; follow up; kidney cancer; onset age; time of death; motor performance; hypertension; diabetes mellitus; infection; heart disease; brain hemorrhage; prostate cancer; levodopa; vascular disease; Parkinson disease; metastasis; pneumonia; disease duration; treatment response; brain depth stimulation; peritonitis; thrombosis; prostate hypertrophy; brain ischemia; dyslipidemia; phenotype; respiratory tract infection; urolithiasis; young adult; colon cancer; intervertebral disk hernia; Unified Parkinson Disease Rating Scale; long term survival