Citation

Bag A, Ghosh K, Saumyajit Ghosh AB, Acharyya A, Pal M. Toxicol. Int. 2015; 22(3): 70-75.

Copyright

(Copyright © 2015, Society of Toxicology India)

DOI

10.22506/ti/2015/v22/i3/137627

PMID

unavailable

Abstract

Organophosphorus (OP) compounds are widely used insecticides in this part of the world. Organophosphorus compounds are responsible for a majority of suicidal attempt in India due to its easy availability. To determine the effect of organophosphorus compounds on hepatobiliary, pancreas, and muscular system and association of biochemical markers of respective systems to determine the outcome. This is a single-center, observational, prospective study conducted on 150 organophosphorus (OP) poisoning patients diagnosed clinically and with circumferential evidence. After admission, relevant biochemical markers of respective systems were done with standard guidelines. In patients where abnormality was found in serum amylase and lipase levels, ultrasonography and/or contrast-enhanced computed tomography evaluation of abdominal organs was done as per clinical indication. Among 150 patients, 17 (11.33%) patients succumbed to death. A significant association was observed between lipase level and treatment outcome. The odds ratio of death among high-level lipase group was 11.54 times higher than normal lipase group. Only four patients developed isolated creatine phosphokinase elevation with features suggestive of rhabdomyolysis. Isolated hepatic enzyme derangements found in only one case, whereas 5 patients had concurrent elevated lipase level. Organophosphorus-induced pancreatitis with or without hepatitis is often overlooked in acute poisoning which may be fatal. An early intervention often reverses this dreaded complication. © 2015 Informatics Publishing Limited and The Society of Toxicology. All rights reserved.

Language: en

Keywords

adult; human; female; male; chlorpyrifos; suicide attempt; C reactive protein; treatment outcome; rhabdomyolysis; intoxication; pancreatitis; major clinical study; unclassified drug; middle aged; albumin; albumin blood level; computer assisted tomography; prospective study; lipid blood level; Lipase; triacylglycerol lipase; hepatitis; alanine aminotransferase; aspartate aminotransferase; creatine kinase; liver injury; organophosphate insecticide; sodium; sodium blood level; creatinine; creatinine blood level; potassium blood level; urea; urea blood level; echography; lipid; calcium; fenthion; amylase; amylase blood level; calcium blood level; biochemical marker; Article; observational study; parathion methyl; bilirubin; bilirubin blood level; alanine aminotransferase blood level; aspartate aminotransferase blood level; creatine kinase blood level; sodium ion; liver function; young adult; fenitrothion; triacylglycerol lipase blood level; pancreas enzyme; muscle injury; Chemical Hepatitis; Creatine Phosphokinase; globulin; globulin blood level; Organophosphorus Poisoning; temphos