Citation

Maier S, Balasa R, Buruian M, Maier A, Bajko Z. Romanian Journal of Neurology/ Revista Romana de Neurologie 2015; 14(1): 22-29.

Copyright

(Copyright © 2015)

DOI

unavailable

PMID

unavailable

Abstract

Depression is one of the most important psychiatric comorbidity in multiple sclerosis and is associated with increased disability and poor quality of life. The diagnosis is challenging because of the overlapping symptomatology. The pathogenesis is complex and controversial, the incidence is high, but is frequently under-diagnosed and under-treated. The aim of this article is to review the most important aspects of depression in multiple sclerosis as: epidemiology, pathogenesis, assessment, correlates with disability, cognition, fatique, quality of life, suicide, the relationship with the immunomodulatory therapy, neuroimaging and treatment options. © 2015 Editura Medicala AMALTEA. All rights reserved.

Language: en

Keywords

disability; human; Depression; suicide; Review; quality of life; exercise; depression; prevalence; Multiple sclerosis; neuroimaging; fatigue; questionnaire; cognitive defect; desipramine; paroxetine; sertraline; duloxetine; DSM-IV; immune system; Beck Depression Inventory; multiple sclerosis; interleukin 6; beta interferon; Montgomery Asberg Depression Rating Scale; beta1a interferon; Hospital Anxiety and Depression Scale; immunomodulation; interleukin 1; interferon beta serine; randomized controlled trial (topic); tumor necrosis factor; Zung Self Rating Depression Scale; Hamilton Depression Rating Scale; assessment of humans; Center for Epidemiologic Studies Depression Rating Scale; Chicago Multiscale Depression Inventory