Citation

Amalnath DS. Indian J. Hematol. Blood Transfus. 2020; 36(3): 473-476.

Copyright

(Copyright © 2020, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s12288-019-01137-2

PMID

unavailable

Abstract

Immunosuppressive therapy (IST), consisting of anti thymocyte globulin and cyclosporine, is the standard of care for elderly patients and in younger patients without matched donor for stem cell transplant. In this retrospective study of 60 patients, most had non severe AA (51.6%) followed by very severe AA (26.7%) and severe AA (21.7%). The response rate at 6 months was 68.3% (complete response-3.3% and partial response-65%). Of the 45 who completed 12 months follow up, RR was 54.7% (CR-7.5%, PR-47.2 %).Eight patients died during the study period. Also, Indian data on IST is briefly reviewed. © 2019, Indian Society of Hematology and Blood Transfusion.

Language: en

Keywords

adolescent; adult; human; suicide; female; male; India; treatment outcome; disease severity; major clinical study; controlled study; retrospective study; human cell; unclassified drug; sepsis; follow up; leukocyte count; liver cirrhosis; immunosuppressive treatment; aplastic anemia; immunosuppressive agent; treatment response; thymocyte antibody; Article; treatment duration; serum sickness; lung hemorrhage; invasive candidiasis; Aplastic anemia; tertiary care center; platelet count; cyclosporine; hypertrophy; ATG; thymogam; Thymogam