Citation

Chen X, Hu L, Tong C. Journal of International Oncology 2008; (12): 566-569.

Copyright

(Copyright © 2008)

DOI

unavailable

PMID

unavailable

Abstract

Tumor-specific promoters can induce high-efficiency and specific expression of exogenous genes in tumor cells. At present, commonly used promoters include alpha-fetoprotein promoter, carcinoembryonic antigen promoter,prostate specific antigen promoter,human telomerase reverse transcriptase promoter and multidrug resistance gene promoter and etc. Dual promoters, enhancer, regulatory element and other physical or chem-ical factors could be used to reconstruct or modify promoters to increase the expression and location of exogenous genes in tumor cells. Tumor-specific promoters play an important role in cancer gene targeted therapy by cou-pling with suicide gene, anti- oncogene, antiseuse nucleic acid, apoptosis gene and RNA interference.

Language: zh

Keywords

Neoplasms; Genes; Target therapy; Transcription initiation site