Citation

Fujimoto K, Sakata T, Ookuma K, Kurokawa M, Yamatodani A, Wada H. Experientia 1990; 46(3): 283-285.

Copyright

(Copyright © 1990, Birkhäuser Verlag)

DOI

10.1007/BF01951767

PMID

2311719

Abstract

Histamine content in the rat hypothalamus was lower at 4 degrees C and higher at 31 degrees C compared to that at 21 degrees C. Pretreatment with alpha-fluoromethylhistidine, a 'suicide' inhibitor of histamine decarboxylase, attenuated both the increased level of hypothalamic histamine and rat adaptive behavior at 31 degrees C. Increase of histamine content in the hypothalamus appears to be an important factor contributing to rat adaptive behavior to high environmental temperature.

Language: en

Keywords

Adaptation, Physiological; Animals; Behavior, Animal; Body Temperature; Cold Temperature; Eating; Histamine; Histidine Decarboxylase; Hot Temperature; Hypothalamus; Male; Methylhistidines; Motor Activity; Rats; Rats, Inbred Strains