Citation

Kukhar VP, Yagupolskii YL, Soloshonok VA. Russian Chemical Reviews 1990; 59(1): 89-102.

Copyright

(Copyright © 1990)

DOI

10.1070/RC1990v059n01ABEH003512

PMID

unavailable

Abstract

The review gives a systematic account of data concerning the methods of synthesis of α-, β-, and γ-aminoacids containing fluorine atoms in the β-position relative to the aminogroup. The interest in these compounds is in many respects due to the fact that most of them have proved to be hijghly selective irreversible inhibitors of pyridoxal-5-phosphate-dependent enzymes acting via the "suicide-substrate" mechanism. Attention is concentrated on β-fluoro-derivatives of natural α -aminoacids. © 1990 The Chemical Society.

Language: en

Keywords

Amino group; Fluorine atoms; Methods of synthesis; Pyridoxal 5' phosphates