Citation

Cerase A, Leonini S, Bellini M, Chianese G, Venturi C. J. Neuroimaging. 2011; 21(3): 283-286.

Copyright

(Copyright © 2011, Wiley)

DOI

10.1111/j.1552-6569.2010.00530.x

PMID

20977538

Abstract

BACKGROUND AND PURPOSE: Effects of methadone misuse have been rarely described. The purpose of this case report is to increase the knowledge of methadone-related leukoencephalopathy.
METHODS: We report the long-term follow-up by brain magnetic resonance imaging including isotropic diffusion-weighted imaging and mean apparent diffusion coefficient values of a 49-year-old patient who attempted suicide by intravenous methadone.
RESULTS AND CONCLUSIONS: Lesion pattern included subtle cerebellar involvement, mainly reversible extensive bilateral and symmetric brain involvement, cystic degeneration in the periventricular regions, sparing of corpus callosum and subcortical U-fibers, development of diffuse brain atrophy, and clear-cut clinical improvement.

Language: en

Keywords

Humans; Male; Middle Aged; Magnetic Resonance Imaging; Brain; Methadone; Brain Mapping; Leukoencephalopathies