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Journal Article

Citation

Jackson MH, Payne HA. Vet. Hum. Toxico. 1995; 37(4): 323-326.

Affiliation

Macfarlan Smith Ltd., Edinburgh, Scotland, United Kingdom.

Copyright

(Copyright © 1995, American College of Veterinary Toxicologists)

DOI

unavailable

PMID

8540219

Abstract

Ethylene glycol automobile engine coolants and methanol-based windshield washer liquids are toxic. Despite international attempts to improve the safety of these products through better labelling and packaging, accidental and intentional ingestions continue a source of poisonings worldwide. The rejection of bitter tasting substances forms part of the human defense against ingestion of harmful substances. Denatonium benzoate (DB) is currently recognised as a means to prevent ingestion of ethyl alcohol intended for industrial use. This study investigated the use of this bitter substance also as a deterrent against ingesting ethylene glycol and methanol. The palatability of ethylene glycol and methanol with and without the addition of DB was assessed using a human taste panel; 30 ppm DB rendered each product intolerable to the panel. The addition of DB to ethylene glycol engine coolants and methanol-based windshield washer liquids at low concentrations could afford protection against accidental ingestions.


Language: en

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