SAFETYLIT WEEKLY UPDATE

We compile citations and summaries of about 400 new articles every week.
Email Signup | RSS Feed

HELP: Tutorials | FAQ
CONTACT US: Contact info

Search Results

Journal Article

Citation

Alexandrov YI, Grinchenko YV, Shevchenko DG, Averkin RG, Matz VN, Laukka S, Korpusova AV. Acta Physiol. Scand. 2001; 171(1): 87-97.

Affiliation

Laboratory of Neural Basis of Mind, Institute of Psychology, Russian Academy of Sciences, Moscow, Russia.

Copyright

(Copyright © 2001, John Wiley and Sons)

DOI

unavailable

PMID

11350267

Abstract

A new need is associated with the formation of behaviour directed at its satisfaction. In chronically ethanol-treated rabbits a bodily need develops to acquire and consume alcohol. The present study examined the firing properties of single neurones in the cingulate (limbic) cortex of chronically ethanol-treated rabbits. The main questions of this study were: are there neurones in the cingulate cortex which specifically increase their firing during alcohol-acquisition behaviour (AAB)? What is the relationship between the neuronal mechanisms of pre-existing and newly formed behaviour? Adult rabbits were taught to acquire food by pressing pedals. After 9 months of ethanol treatment, the same rabbits were taught to acquire ethanol (15% solution in a 0.5-mL capsule) by means of the same instrumental METHOD: Activity of the 118 neurones was recorded from the cingulate cortex. The comparison of activity of each neurone in AAB and food-acquisition behaviour (FAB) enabled us to reveal that their subservings overleap substantially but not completely: 41% of 'common neurones' involved in the subserving of both FAB and AAB as well as 5% of 'alcohol-neurones' (alcohol-acquisition specific cells) were found. We think of the latter neurones as units that were specialized during the forming of alcohol-seeking behaviour. Thus, present experiments help us not only to answer the above questions but also to provide an additional insight into the nature of similarity between neuronal mechanisms of long-term memory and long-lived modifications resulting from repeated drug exposure.


Language: en

NEW SEARCH


All SafetyLit records are available for automatic download to Zotero & Mendeley
Print