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Journal Article


Dobry Y, Novakovic V, Barkin RL, Sundaram VK. Am. J. Ther. 2014; 21(1): e1-6.


1Department of Psychiatry, Mount Sinai School of Medicine, New York, NY; 2Department of Anesthesiology, Northshore University Health System, Evanston, IL; and Departments of 3Anesthesiology, 4Family Medicine, and 5Pharmacology, Rush University Medical Center, Chicago, IL.


(Copyright © 2014, Lippincott Williams and Wilkins)






A patient with progressively worsening auditory hallucinations and 30-year history of traumatic brain injury (TBI) was reported. To formulate a comprehensive diagnostic and treatment approach to patients with auditory sensory disturbances and other neuropsychiatric sequela of a TBI, an electronic search of the major behavioral science databases (Pubmed, PsycINFO, Medline) and a textbook review were conducted to retrieve studies detailing the clinical characteristics, biological mechanisms, and therapeutic approaches to post-TBI psychosis. Additional references were incorporated from the bibliographies of the retrieved articles. Although infrequent, auditory hallucinations is a debilitating complication of TBI that can manifest itself 4-5 years after the occurrence of TBI. Because the age range of TBI survivors is 15-24 years, and the chance of developing post-TBI psychosis is reported to be up to 20%, this chronic neuropsychiatric complication and the available treatment options warrant close scrutiny from the clinical and the biomedical research community. Our case report and literature review demonstrates a clear need for a large, well-designed randomized trials to compare properties and efficacies of different, available, and promising pharmacotherapy agents for the treatment of post-TBI psychosis.

Language: en


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