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Journal Article

Citation

Sparks DL, Oeltgen PR, Kryscio RJ, Hunsaker JC. J. Forensic Sci. 1989; 34(1): 197-206.

Affiliation

Sanders-Brown Research Center on Aging, University of Kentucky Medical Center, Lexington.

Copyright

(Copyright © 1989, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

unavailable

PMID

2918279

Abstract

Accurate determination of postmortem interval (PMI) is a problem for the forensic thanatologist, especially in unwitnessed deaths. A number of objective chemical methods for determining PMI have been developed, the most widely used being accumulation of potassium in the vitreous humor. The authors previously have reported a chemical method for determining PMI from the predictable accumulation or clearance of the dopaminergic metabolite 3-methoxytyramine (3-MT) in the putamen of the brain. They have extended their previous study to compare directly the accuracy of determining PMI from the level of 3-MT in putamen with the level of potassium in vitreous humor. The data indicate that 3-MT is at least as accurate as, if not more accurate than, potassium accumulation in vitreous humor, although 3-MT levels can be affected by the cause of death and drugs present at the time of death. Nevertheless, determination of both the 3-MT and potassium levels can afford the most accurate method of determining PMI; preliminary nomograms for determining PMI from both variables are presented.


Language: en

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