Citation

Brundin L, Björkqvist M, Träskman-Bendz L, Petersen A. J. Affect. Disord. 2009; 113(1-2): 179-182.

Affiliation

Division of Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden. Lena.Brundin@med.lu.se

Copyright

(Copyright © 2009, Elsevier Publishing)

DOI

10.1016/j.jad.2008.04.011

PMID

18533274

Abstract

BACKGROUND: The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to specific psychiatric symptoms. METHODS: Ten patients took part in lumbar punctures and psychiatric evaluations in conjunction to a suicide attempt and after 6 and 12 months. We measured CSF-orexin and CART using radioimmunoassays. RESULTS: Mean CSF-orexin was significantly higher at the first and second follow-up than at the suicide attempt. In contrast, mean CSF-CART did not differ over time. Total SUAS scores, as well as ratings of CPRS item 66 (global illness) were significantly lower at follow-up. At one year, there was a significant negative correlation between the change in CSF-orexin and the change in total SUAS score. LIMITATIONS: The number of patients who participated was relatively small. CONCLUSIONS: Our results support the hypothesis that orexin is involved in psychiatric symptomatology.

Language: en