Citation

Herman BH, Hammock MK, Arthur-Smith A, Egan J, Chatoor I, Werner A, Zelnik N. Ann. Neurol. 1987; 22(4): 550-552.

Affiliation

Brain Research Center, Children's Hospital National Medical Center, Washington, DC 20010.

Copyright

(Copyright © 1987, John Wiley and Sons)

DOI

10.1002/ana.410220419

PMID

3481242

Abstract

The effect of naltrexone (0.5, 1.0, 1.5, and 2.0 mg/kg) on the frequency of self-injurious behavior (SIB) was investigated in three male adolescents. The frequency of total SIB was reduced significantly in all three subjects; dose-dependent decreases (at 0.5, 1.0, and 1.5 mg/kg) in SIB frequency were observed in the two mentally retarded subjects. These data suggest a role for opioid peptides in SIB.

Language: en