Citation

O'Keane V, Moloney E, O'Neill H, O'Connor A, Smith C, Dinan TG. Br. J. Psychiatry 1992; 160: 643-646.

Affiliation

Psychiatric Unit, St James's Hospital, Dublin, Republic of Ireland.

Comment In:

Br J Psychiatry 1992;161:721

Copyright

(Copyright © 1992, Royal College of Psychiatry)

DOI

unavailable

PMID

1591573

Abstract

Using a neuroendocrine probe we studied nine male offenders in a forensic hospital, convicted of murder, with a diagnosis of antisocial personality disorder, who had been behaviourally 'quiescent' for varying periods and who had not recently been abusing drugs. Nine healthy age-matched men also participated. All subjects received 30 mg d-fenfluramine (d-FEN), a 5-HT releasing agent, orally, after an overnight fast, and serial samples for prolactin estimation were taken hourly for five hours. Responses were significantly impaired in the patients, suggesting a subsensitivity of certain 5-HT systems in antisocial personality disorder, regardless of recent or ongoing behavioural disturbance.

Language: en