Citation

Ruiz J, Gabilondo AM, Meana JJ, García-Sevilla JA. Psychopharmacology 1992; 109(4): 410-414.

Affiliation

Department of Pharmacology, University of the Basque Country, Leioa, Bizkaia.

Copyright

(Copyright © 1992, Holtzbrinck Springer Nature Publishing Group)

DOI

unavailable

PMID

1365855

Abstract

The specific binding of the D2-dopamine receptor antagonist radioligand 3H. raclopride was quantitated in the postmortem caudate and frontal cortex from schizophrenic suicide victims and control subjects. In schizophrenic suicides the density of binding sites (Bmax) was higher (40%, P < 0.05) in the caudate, whereas it did not change in the cortex as compared to those in controls. The apparent dissociation constants (KD) were also found increased both in caudate (24%) and cortex (75%) from schizophrenics, but these apparent decreases in receptor affinity did not reach statistical significance. The mean Bmax value in drug-free schizophrenic suicides (n = 3) did not differ from the Bmax value in neuroleptic drug-treated schizophrenics (n = 7) but it was found increased in respect to control subjects (n = 9). No differences in 3H. raclopride binding were observed between non-schizophrenic suicide victims (n = 4) and matched controls (n = 4), suggesting that the modifications of D2-dopamine receptors in schizophrenia are not related to suicide.

Language: en