Citation

Muck-Seler D, Jakovljevic M, Pivac N. J. Affect. Disord. 1996; 39(1): 73-80.

Affiliation

Laboratory for Molecular Neuropharmacology, Ruder Bosković Institute, Zagreb, Croatia. seler@olimp.irb.hr

Copyright

(Copyright © 1996, Elsevier Publishing)

DOI

unavailable

PMID

8835656

Abstract

Platelet 5-HT concentrations were determined in 84 male and 82 female psychotic and non-psychotic depressed inpatients with various degrees of suicidal behaviour, and in 175 healthy controls. Psychotic patients had higher platelet 5-HT concentrations than non-psychotic depressed patients and healthy controls. A sex difference, i.e., lower platelet 5-HT concentrations in females was found in healthy controls, depressed patients, non-psychotic patients and non-suicidal depressed patients. A negative relationship was shown between platelet 5-HT concentrations and suicidal behaviour. The lowest platelet 5-HT concentrations were associated with the most pronounced suicidal behaviour (with suicidal attempts and with the acts of suicide). The results suggest that the differences in platelet 5-HT concentrations found in depressed patients might be used as a biological marker for suicidal behaviour.

Language: en