Citation

Musshoff F, Stamer UM, Madea B. Forensic Sci. Int. 2010; 203(1-3): 53-62.

Affiliation

Institute of Forensic Medicine, Stiftsplatz 12, 53111 Bonn, Germany.

Copyright

(Copyright © 2010, Elsevier Publishing)

DOI

10.1016/j.forsciint.2010.07.011

PMID

20828952

Abstract

Large inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with its target often are determined by genetic differences. Pharmacokinetic and pharmacodynamic variations can appear at the level of drug metabolizing enzymes (e.g., the cytochrome P450 system), drug transporters, drug targets or other biomarker genes. Pharmacogenetics or toxicogenetics can therefore be relevant in forensic toxicology. This review presents relevant aspects together with some examples from daily routines.

Language: en