Citation

Zink BJ, Szmydynger-Chodobska J, Chodobski A. Psychiatr. Clin. North Am. 2010; 33(4): 741-756.

Affiliation

Department of Emergency Medicine, Alpert Medical School of Brown, University Rhode Island Hospital & The Miriam Hospital, 593 Eddy Street, Claverick 2, Providence, RI 02903, USA.

Copyright

(Copyright © 2010, Elsevier Publishing)

DOI

10.1016/j.psc.2010.08.005

PMID

21093676

Abstract

A complex set of molecular and functional reactions is set into motion by traumatic brain injury (TBI). New research that extends beyond pathological effects on neurons suggests a key role for the blood-brain barrier, neurovascular unit, arginine vasopressin, and neuroinflammation in the pathophysiology of TBI. The prevalence of molecular derangements in TBI holds promise for the identification and use of biomarkers to assess severity of injury, determine prognosis, and perhaps direct therapy. Hopefully, improved knowledge of these elements of pathophysiology will provide the mechanistic clues that lead to improved treatment of TBI.

Language: en