Citation

Waddington JL, Youssef HA. Br. J. Psychiatry 1988; 153: 376-381.

Affiliation

Royal College of Surgeons, St Stephen's Green, Dublin, Ireland.

Copyright

(Copyright © 1988, Royal College of Psychiatry)

DOI

unavailable

PMID

2907977

Abstract

The demography, psychiatric morbidity, and motor consequences of long-term neuroleptic treatment in the 14 children born to a father with a family history of chronic psychiatric illness and a mother with a late-onset affective disorder resulting in suicide are documented. Twelve siblings lived to adulthood, nine of whom were admitted to a psychiatric hospital in their second or third decade, and required continuous in-patient care; five remaining in hospital, with long-term exposure to neuroleptics, had chronic, deteriorating, schizophrenic illness and emergence of movement disorder. Two siblings showed no evidence of psychosis but developed a late-onset affective disorder. The implications for the issues of homotypia, vulnerability to involuntary movements, and interaction with affective disorder are discussed.

Language: en