Citation

Rende R, Birmaher B, Axelson DA, Strober M, Gill MK, Valeri S, Chiappetta L, Ryan N, Leonard H, Hunt J, Iyengar S, Keller M. J. Affect. Disord. 2006; 96(1-2): 127-131.

Affiliation

Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA. Richard_Rende@Brown.edu

Copyright

(Copyright © 2006, Elsevier Publishing)

DOI

10.1016/j.jad.2006.05.022

PMID

16814395

Abstract

BACKGROUND: Few studies have examined the specificity and non-specificity in patterns of familial loading for presentation of psychotic symptoms in pediatric bipolar disorder (BP). METHODS: Diagnostic assessment of 263 pediatric BP probands included lifetime history of psychotic symptoms as well as longitudinal follow-up; family history of psychiatric illness was determined for 1st degree relatives. RESULTS: Pediatric BP probands with lifetime history of psychosis had a higher percentage of positive family history of anxiety disorders and suicide attempts as compared to probands with no history of psychosis. DISCUSSION: Familial loading for a spectrum of internalizing disorders is associated with presentation of psychotic symptoms in pediatric BP.

Language: en