Citation

Lawrence KM, Kanagasundaram M, Lowther S, Katona CL, Crompton MR, Horton RW. J. Affect. Disord. 1998; 47(1-3): 105-112.

Affiliation

Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.

Copyright

(Copyright © 1998, Elsevier Publishing)

DOI

unavailable

PMID

9476750

Abstract

Using desmethylimipramine (DMI) defined and Na+ dependent [3H]imipramine binding, we have examined both 5-HT uptake sites and sites unrelated to 5-HT uptake, in frontal cortex, putamen and substantia nigra of suicides with a firm retrospective diagnosis of depression and matched controls. No differences were seen between antidepressant-free suicides and controls, although [3H]imipramine binding sites were significantly lower in putamen of the subgroup of non-violent suicides. The number of DMI defined [3H]imipramine binding sites was also significantly lower in putamen of antidepressant-treated suicides.

Language: en