Citation

Lowther S, Crompton MR, Katona CL, Horton RW. Mol. Psychiatry 1996; 1(6): 470-477.

Affiliation

Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London, UK. slowther@sghms.ac.uk

Copyright

(Copyright © 1996, Nature Publishing Group)

DOI

unavailable

PMID

9154249

Abstract

We have measured basal, guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) and forskolin-stimulated adenylyl cyclase activity in samples of frontal and parietal cortex obtained at post-mortem from suicides, with a firm retrospective diagnosis of depression. The suicides were divided into those free of antidepressants and those receiving antidepressants. Each suicide was individually compared to a gender and age-matched control. Although we found no significant differences in adenylyl cyclase activity between controls and either antidepressant-free or antidepressant-treated suicides, there was a trend for lower stimulated adenylyl cyclase activity in suicides.

Language: en