Citation

Marazziti D, Dell'Osso L, Rossi A, Masala I, Baroni S, Armani A, Giannaccini G, Di Nasso E, Lucacchini A, Cassano GB. Psychiatry Res. 2001; 103(2-3): 125-131.

Affiliation

Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, via Roma, 67, 56100, Pisa, Italy. dmarazzi@psico.med.unipi.it

Copyright

(Copyright © 2001, Elsevier Publishing)

DOI

unavailable

PMID

11549401

Abstract

Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([3H]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [3H]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior.

Language: en