Citation

Vogel JJ, de Moerloose P, Bouvier CA, Gaspoz J, Riant P. Schweiz. Med. Wochenschr. 1988; 118(50): 1915-1917.

Vernacular Title

Anticoagulation prolongee lors d'une intoxication a la chlorphacinone.

Affiliation

Département de médecine, Hôpital cantonal universitaire, Genève.

Copyright

(Copyright © 1988, EMH Swiss Medical Publishers)

DOI

unavailable

PMID

3222685

Abstract

In 1985 and 1986 the Swiss Toxicologic Information Center registered 152 cases of rodenticide poisoning. Among those substances chlorophacinone, an indanedione derivative, has a prolonged antivitamin K effect. We report here the case of an eighteen-year-old female hospitalized 3 days after deliberately ingesting some 100 mg chlorophacinone. Her Quick time at admission was less than 10% (Prothrombin time 79 sec., normal control 12 sec.). Under high dose vitamin K therapy the Quick was rapidly corrected but fell again on each vitamin K withdrawal. In a search for a relation between the variations of prothrombin time and chlorophacinone plasma levels, these were assessed by HPLC. Prothrombin time (and vitamin K dependent factors VII and X) finally normalized only 7 weeks after chlorophacinone ingestion. Clinical condition remained satisfactory throughout and other biological parameters unaffected. This case emphasizes the need for prolonged clinical and laboratory follow-up for rodenticide intoxications and for vitamin K administration for several weeks.

Language: fr