Citation

de Roodt AR, Gutiérrez LR, Rufino Caro R, Lago NR, Montenegro JL. Arch. Argent. Pediatr. 2011; 109(1): 62-65.

Vernacular Title

Obtencion de un antiveneno contra el veneno de Phoneutria nigriventer (arachnida;

Affiliation

Área Investigación y Desarrollo/Serpentario, ANLIS Dr. Carlos G. Malbrán, Ministerio de Salud de la Nación.

Copyright

(Copyright © 2011, Sociedad Argentina de Pediatria)

DOI

10.1590/S0325-00752011000100014

PMID

21283947

Abstract

Envenomation by spiders of the genus Phoneutria ("banana spider") may be lethal, especially in children. The only available specific treatment is the use of antivenom, which is produced by only one laboratory in the world. In this study we report the development of an equine F (ab')2 experimental antivenom raised against the venom of Phoneutria nigriventer. The antivenom neutralized the venom of spiders from different regions of Argentina (Misiones and Jujuy), the development of envenomation symptoms in experimental animals was totally inhibited. These results show that local production of this type of antivenom is possible. Independence of production is important since international acquisition is always conditioned by the availability of stock surplus from the sole producer.

Language: es